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PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 22
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DeCS
Descriptor
Inglés
:
Protein Tyrosine Phosphatase, Non-Receptor Type 22
Descriptor
Español
:
Proteína Tirosina Fosfatasa no Receptora Tipo 22
Descriptor
Portugués
:
Proteína Tirosina Fosfatase não Receptora Tipo 22
Categoría:
D08.811.277.352.650.775.300.930
D12.644.360.585.930
D12.776.476.564.930
Definición
Inglés
:
A subtype of non-receptor
protein tyrosine phosphatases
that is characterized by the presence of an N-terminal
catalytic domain
and a C-terminal PROLINE-rich domain. The phosphatase subtype is predominantly expressed in
LYMPHOCYTES
and plays a key
role
in the inhibition of downstream T-LYMPHOCYTE activation. Polymorphisms in the gene that encodes this phosphatase subtype are associated with a variety of
AUTOIMMUNE DISEASES.
Nota Histórica
Inglés
:
2008(1999)
Calificadores Permitidos
Inglés
:
AD
administration & dosage
AE
adverse effects
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DU
diagnostic use
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Número del Registro:
52703
Identificador Único:
D054596
Ocurrencia en la BVS
:
Similar:
DeCS
CID-10
SciELO
LILACS
LIS